• Substantiating the role of proteostasis in the

  2019-07-06

  

  Substantiating the role of proteostasis in the aging heart remains a challenging task between species and even among individuals of the same species with similar genetic backgrounds [24]. As described above, microarray analysis of roughly 30 pooled adult Drosophila hearts highlighted an important ro

• Introduction Heritability of human longevity has been estima

  2019-07-05

  

  Introduction Heritability of human longevity has been estimated as 15–40% [[1], [2], [3], [4], [5], [6], [7], [8], [9]], although recent data from 5.3 million family trees of up to 13 million members generated from 86 million public profiles on an online genealogy database obtained an estimate of 1

• Glycosylation is arguably one of

  2019-07-05

  

  Glycosylation is arguably one of the most difficult PTMs to analyze via mass spectrometry. Unlike with acetylation or phosphorylation, where the addition of a standard group can be accounted for due to expected mass shifts, glycosylation occurs through the addition of varying isobaric glycans [35].

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