Substantiating the role of proteostasis in the
Substantiating the role of proteostasis in the aging heart remains a challenging task between species and even among individuals of the same species with similar genetic backgrounds . As described above, microarray analysis of roughly 30 pooled adult Drosophila hearts highlighted an important ro
Introduction Heritability of human longevity has been estima
Introduction Heritability of human longevity has been estimated as 15–40% [, , , , , , , , ], although recent data from 5.3 million family trees of up to 13 million members generated from 86 million public profiles on an online genealogy database obtained an estimate of 1
Glycosylation is arguably one of
Glycosylation is arguably one of the most difficult PTMs to analyze via mass spectrometry. Unlike with acetylation or phosphorylation, where the addition of a standard group can be accounted for due to expected mass shifts, glycosylation occurs through the addition of varying isobaric glycans .