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Other studies have reported on the
2019-09-02
Other studies have reported on the prognostic significance of the LCSS ASBI and patient-reported outcomes in general [[20], [21], [22], [23], [24], [25]]. From a meta-analysis of 30 randomized controlled trials of 11 different tumor types from the European Organization for Research and Treatment of
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While this study indicates that approximately of patients
2019-08-26
While this study indicates that approximately 10% of patients treated with afatinib are likely to be LTRs, we were unable to identify any baseline clinical or tumor characteristics that could potentially identify patients most likely to achieve long-term benefit. The baseline characteristics of afat
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br Materials and methods br Results br Discussion
2019-08-26
Materials and methods Results Discussion To the best of our knowledge, ours is the first study to examine the relationship between the immune microenvironment and 18F-FDG PET results in patients with SCLC. The low expressions of CD8 and CD4 correlated with a high 18F-FDG uptake. Our study a
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In Italy AIRTUM presented comprehensive epidemiological data
2019-08-16
In Italy, AIRTUM presented comprehensive epidemiological data about the incidence (and prevalence) of STS and the associated survival of those affected [1]. The distribution of cancer registries in Italy covers most of the regions where expert centres are available, other than Bologna. In addition,
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br Materials and methods br Results The baseline
2019-08-16
Materials and methods Results The baseline characteristics of cancer survivors, CDZ, and CNDZ are shown in Table 1. The distribution of marital status, education, household income, employment status, self-rated health status, family history of cancer, current smoking status, current drinking s
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br Conclusion br Declaration of interest This project was fu
2019-08-11
Conclusion Declaration of interest This project was funded by the Richdale Charitable Trust. The funder had no role in the design, analysis, interpretation, write-up or publication of this study. Author statement Introduction Malignant mesothelioma is a rare disease that results from th
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PAK and are ubiquitously expressed in humans and
2019-07-30
PAK2 and 4 are ubiquitously expressed in humans and mice and both these genes are required for embryonic development in mice [34]. Pak2 null mice die at embryonic day 8 (E8.0) with prominent defects in vascularization whereas PAK4 ablation causes lethality at E11.5, from heart defects, impairments i
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We have not observed elevated cytokine levels in
2019-07-30
We have not observed elevated cytokine levels in non-infected naïve Dp10 mice, although elevated levels of pro-inflammatory cytokines have been reported in individuals with DS not suffering from an infection [10]. Beyond the fact that experimental mice are kept in an otherwise sterile environment un
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In a study by the Landreth group the administration of
2019-07-24
In a study by the Landreth group [10], the administration of bexarotene, a retinoid X receptor (RXR) agonist used as a treatment for cutaneous T cell lymphoma, reduced Aβ levels in the Acarbose and restored cognitive function in AD mouse models within only 7 days of treatment. Thus, bexarotene may
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Dalbavancin Limitations in accuracy and True Positive Rates
2019-07-24
Limitations in accuracy and True Positive Rates of biomarker predictions with existing methods and models, may have different causes. Cellular lipid profiles are very complex [19], and currently incompletely represented in the human genome-scale models. Since many flavoprotein-related diseases affec
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LIN exhibits high expression in
2019-07-11
LIN28 exhibits high expression in embryonic stem PSB 1115 (ESCs) and its expression level is reduced upon differentiation [6,7]. Accordingly, LIN28 is a stem cell core factor and participates in cellular reprogramming [[8], [9], [10]]. Moreover, LIN28-expressing cancers demonstrate a less-different
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Pimozide Introduction The failing heart has been considered
2019-07-11
Introduction The failing heart has been considered as an “energy-starved engine that has run out of fuel” [1,2]. For an adult heart, the turnover of ATP per day has been estimated to be 6 kg. The heart converts chemical energy stored in fatty acids, lactate, and glucose into the mechanical energy t
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The following are the supplementary data
2019-07-08
The following are the supplementary data related to this article. Transparency document Acknowledgements We thank the other members of the Van Eck group for their practical support during the experiments. We acknowledge the support from the Netherlands CardioVascular Research Initiative: the
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NPS-2143 The phenotypes of ESCS Nr e zebrafish
2019-07-08
The phenotypes of ESCS, Nr2e3 zebrafish, Nrl mouse and rd7 mouse demonstrate that Nr2e3 has a critical role for rod development in zebrafish and human. By contrast, it is Nrl that modulates rod development in mouse. However, Nrl alone is not sufficient to maintain rod survival in rd7 mouse. Therefor
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Currently DMPO or any of its structural analogs have
2019-07-08
Currently, DMPO or any of its structural analogs, have not been moved into the drug development pipeline. That may be due to DMPO synthesis being really expensive in comparison to PBN and its derivatives. PBN-analogs have been synthesized and their anti-inflammatory properties have been tested in di