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    63 Original Investigation
    Additive Benefit of Radiomics Over Size Alone in the Distinction Between Benign Lesions and Luminal A Cancers on a Large Clinical Breast MRI Dataset
    HeatherD1X M. Whitney, PhD,D2X NathanD3X S. Taylor,D4KarenD5X Drukker, PhD,D6X AlexandraD7X V. Edwards, MA,D8X JohnD9X Papaioannou, MS,D10X David1X Schacht, MD,D12X MPH, MaryellenD13X L. Giger, PhDD14X
    Rationale and Objectives: The objective of this study was to demonstrate improvement in distinguishing between benign lesions and luminal A breast cancers in a large clinical breast magnetic resonance imaging database by using quantitative radiomics over maximum linear size alone.
    Materials and Methods: In this retrospective study, 264 benign lesions and 390 luminal A breast cancers were automatically segmented from dynamic contrast-enhanced breast magnetic resonance images. Thirty-eight radiomic features were extracted. Tenfold cross valida-tion was performed to assess the ability to distinguish between lesions and cancers using maximum linear size alone and lesion signatures obtained with stepwise feature selection and a linear discriminant analysis classifier including and excluding size features. Area under the receiver operating characteristic curve (AUC) was used as the figure of merit.
    Results: For maximum linear size alone, AUC and 95% confidence interval was 0.684 (0.642, 0.724) compared to 0.728 (0.687, 0.766) (P = 0.005) and 0.729 (0.689, 0.767) (P = 0.005) for lesion signature feature selection protocols including and excluding size features, respectively. The features of irregularity and entropy were chosen in all folds when size features were included and excluded. AUC for the radiomic signature using feature selection from all features was statistically equivalent to using feature selection from all features excluding size features, within an equivalence margin of 2%.
    Conclusions: Inclusion of multiple radiomic features, automatically extracted from magnetic resonance images, in a lesion signature sig-nificantly improved the ability to distinguish between benign lesions and luminal A breast cancers, compared to using maximum linear size alone. The radiomic features of irregularity and entropy appear to play an important but not a solitary role within the context of feature selection and computer-aided diagnosis.
    Key Words: Breast cancer; MRI; luminal A; radiomics.
    © 2018 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.